Cellulose represents the most abundant renewable and biodegradable biopolymer on earth. The use of bio-based cellulose for the construction of novel functional materials is progressed rapidly in last years. Esterification of cellulose is among the most versatile modifications leading to a wide variety of biopolymers with valuable properties. The esterification can be carried out efficiently through a reactive approach in pyridine using an acyl chloride. The objective of this research was to investigate the formation of cellulose esters with a variety of structural features via this conventional path to obtain advanced materials.